Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease

The mitochondrial permeability transition pore.

This chapter reviews recent advances in the identification of the structural elements of the permeability transition pore. The discovery that cyclosporin A (CsA) inhibits the pore proved instrumental. Various approaches indicate that CsA blocks the pore by binding to cyclophilin (CyP)-D. In particular, covalent labelling of CyP-D in situ by a photoactive CsA derivative has shown that pore ligan...

thallium induces mitochondrial permeability transition pore opening and cytochrome c release: oxidative stress mechanisms

Mitochondrial permeability transition pore: an enigmatic gatekeeper

Mitochondrial permeability transition pore (MPTP) is a transient structure formed in the inner mitochondrial membrane (IMM) upon oxidative challenge of the organelle. The transition is a Ca 2+ -dependent increase of permeability of IMM leading to loss of transmembrane potential (∆ψm), mitochondrial swelling and, finally, rupture of outer mitochondrial membrane leading to release of factors caus...

Mitochondrial permeability transition pore and postconditioning.

Postconditioning has recently been described as a powerful cardioprotection that prevents lethal reperfusion injury. Growing evidence suggests that mitochondrial permeability transition may be a key event in postconditioning. This proposition arises from the complementary observations that: (1) conditions for the mitochondrial permeability transition pore (mPTP) opening are built up during earl...

Amyloid β -peptide Promotes Permeability Transition Pore in Brain Mitochondria

In this work the effect of the neurotoxic amino acid sequence, Aβ25–35 , on brain mitochondrial permeability transition pore (PTP) was studied. For the purpose, the mitochondrial transmembrane potential (∆Ψm), mitochondrial respiration and the calcium fluxes were examined. It was observed that Aβ25–35, in the presence of Ca, decreased the ∆Ψm, the capacity of brain mitochondria to accumulate ca...